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2015-5-4 17:27:24点击:


  

                 

李杨欣

教授,博士生导师

苏州大学心血管病研究所

邮箱:yangxin_li@yahoo.com

主页:http://www.365heart.com/u/liyangxin.html

团队网站:http://lilab.www.gxyhzzj.com.cn/

 







 

发表SCI论文63篇,并有文章发表在Lancet J of clinical InvestigationATVB。其中第一作者或通讯作者文章43篇,累计影响因子409.24。近两年,以第一作者和通讯作者在心血管领域著名杂志CirculationIF19.309)发表文章5篇,在Nat Rev CardiolIF14.299)上发表文章2篇。在美国工作期间,曾主持3项美国心血管学会和麦克当纳基金会项目,成果以第一作者或通讯作者发表论文于CirculationCell CycleInternational J of Cardiology等杂志。现主持国自然面上项目和重点培育项目,国家自然科学基金委员会国际合作项目,江苏省重点科技研发项目,江苏省双创团队临床转化项目和苏州市民生项目。此外,近两年曾获得江苏省双创人才、江苏省双创团队领军、江苏省特聘医学专家、江苏省六大人才高峰创新团队领军、苏州市高层次紧缺人才、中国病理生理学会会员等荣誉称号。


教育与工作经历:


  2013.12 -至今       苏州大学医学部心血管病研究所         教授
 

  2006.7-2013.8       美国德州心血管中心                         研究员


  2003.9-2006.6       美国杜兰大学                                   副教授


  2002.7-2003.9       美国堪萨斯大学                                副教授


  2001.7-2002.6       美国南伊利诺伊大学                         讲师


  1996.7-2001.6       美国佛罗里达大学                             博士后


  1992.1-1996.7       美国佛罗里达大学                             博士


  1984.9-1989.7       中国科技大学                                    学士


 


研究方向:


1. 心血管疾病的发病、诊断和治疗方面的研究


2. 干细胞治疗心血管疾病机制的研究


3. 外泌体(exosome),miRNAlncRNA分子机制的研究


4. 细胞分化机制的研究 


 


荣誉称号与奖励:


 1999        NIH RSA (Research Society on Alcoholism) Junior Investigator Award


2000        NIH RSA (Research Society on Alcoholism) Junior Investigator Award


2005        Chun Hui Award (From P.R China)


2005        American Heart Association (AHA) Merit Award for Young Investigator


2013        Fellow of American Heart Association (FAHA)


2015        江苏省双创人才


2015        江苏省特聘医学专家


2015         苏州市高层次紧缺人才


2016        江苏省双创团队领军


2017        江苏省六大人才高峰创新团队领军


2018     科学中国人


 


学术兼职: 


中国科技部干细胞重点专项评审专家


中国卫计委精准医学重点专项评审专家


中国教育部青年长江和长江特聘教授评审专家


美国心脏学会(AHA)科研基金评审委员


英国糖尿病协会科研经费国外评审委员


  美国心脏学会资深会员(FAHA)


国际心脏研究学会(ISHR)中国分会委员


ISHR中国转化医学工作委员会委员


中国病理生理学会心血管专业委员会委员


Cardiovascular Genetics, Arteriosclerosis, Thrombosis and Vascular Biology (ATVB), PLoS One, Cardiovascular Research, Journal of Molecular and Cellular Cardiology, Apoptosis, The Journal of Pathology, Journal of Lipid Research, Molecular and Cellular Biochemistry, Acta Pharmacologica Sinica, Cytokine, International Journal of Biological Sciences, Experimental Physiology, Journal of Cellular and Molecular Medicine, Molecular Biology Report, Stem Cells, Oncotarget等二十余种国际顶尖杂志的审稿人。


代表性论著:


1. Li Y, Han C, Wang J, Zhou J, Liang C, Ranganna K, Song YH. Exosomes Mediate the Beneficial Effects of Exercise. Adv Exp Med Biol. 1000:333-353, 2017


2. Song YH, Shao L, Zhang Y, Zhou J, Liu B, Pan X, Geng YJ, Yu XY, Li Y. Exosomes Derived from Embryonic Stem Cells as Potential Treatment for Cardiovascular Diseases. Adv Exp Med Biol. 998:187-206, 2017


3. Zhang Y, Pan X, Sun Y, Geng YJ, Yu XY, Li Y(corresponding author). The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging. Muscle Atrophy (pp. 347-368). Springer, Singapore. 2018


代表性文章:


Peer-reviewed Publications (in chronological order)


1. Song YH, Connor E, Li Y, Zorovich B, Balducci P, Maclaren N. The role of tyrosinase in autoimmune vitiligo. Lancet 344:1049-1052, 1994


2. Song YH, Li Y, Maclaren NK. The nature of autoantigens targeted in autoimmune endocrine diseases. Immunol Today  17:232-238, 1996


3. Li Y, Song YH, Rais N, Connor E, Schatz D, Muir A, Maclaren N. Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism. J Clin Invest  97:910-914, 1996


4. Li Y, King MA, Grimes J, Smith N, de Fiebre CM, Meyer EM. Alpha7 nicotinic receptor mediated protection against ethanol-induced cytotoxicity in PC12 cells. Brain Res  816:225-228, 1999


5. Li Y, Papke RL, He YJ, Millard WJ, Meyer EM. Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells. Brain Res  830:218-225, 1999


6. Li Y, King MA, Meyer EM. Alpha7 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells. Brain Res  861:165-167, 2000


7. Li Y (corresponding author), Walker DW, King MA. Peroxide mediates ethanol-induced cytotoxicity in PC12 cells. Free Radic Biol Med  30:389-392, 2001


8. Li Y (corresponding author), Meyer EM, Walker DW, Millard WJ, He YJ, King MA. Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures. J Neurochem  81:853-858, 2002.


9. Li Y, Higashi Y, Itabe H, Song YH, Du J, Delafontaine P. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome c release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol  23:2178-2184, 2003


10. Delfontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 24:435-444, 2004


11. Song YH, Li Y, Du J, Mitch WE, Rosenthal N, Delfontaine P:Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest  115:451-458, 2005


12. Higashi Y, Peng T, Du J, Sukhanov S, Li Y, Itabe H, Parthasarathy S, Delfontaine P. A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor. J Lipid Res  46:1266-1277, 2005


13. Song YH, Godard M, Li Y, Richmond SR, Rosenthal N, Delafontaine P. Insulin-like growth factor-1-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation. J Investig Med  53:135-142, 2005


14. Li Y, Song YH, Mohler J and Delafontaine P. Angiotensin II induces apoptosis of human vascular smooth muscle via an extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression. Am J of Physiol Heart Circ Physiol. 290 (5):H 2116-2123. 2006


15. Li Y (corresponding author), Yu X, Lin S, Li X, Zhang S and Song YH. Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells. Biochem Biophys Res Commun. 356 (3), 780 – 784. 2007.


16. Li Y, Sagar M, Wassler, M, Shelet H and Geng YJ. Apolipoprotein-J Prevention of Cardiac    Myobalst Apoptosis Induced by Ethanol.  Biochem Biophys Res Commun. 357 (1), 157 – 161. 2007


17. Sukhanov S, Higashi Y, Li Y, Song YH, Titterington J, Delafontaine P. IGF-1 Reduces Inflammatory Responses, Suppresses, Oxidative Stress and Decreases Atherosclerosis Progression in Apoe-Deficient Mice. Arterioscler Thromb Vasc Biol. 27 (12): 2684 - 2690.2007


18. Yu X, Song YH, Geng  YJ, Lin Q, Shan Z, Lin S, Li Y (corresponding author). Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1. Biochem Biophys Res Commun. 376 (3), 548-552, 2008


19. Li Y (corresponding author), Song YH, Li F, Yang T, Lu YW, Geng YJ. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem Biophys Res Commun, 381(1): 81-83, 2009


20. Shan ZX, Lin QX, Fu YH, Deng CY, Li Y, Lin SG, Yu XY. Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction. Biochem Biophys Res Commun, 381(4): 597-601, 2009


21. Li Y (corresponding author), Wu H, Khardori R, Song YH, Lu Y W, Geng YJ. Insulin-like growth factor-1 receptor activation prevents high glucose – induced mitochondrial dysfunction, cytochrom c release and apoptosis. Biochem Biophys Res Commun, 384 (2): 259-264, 2009


22. Yu XY, Geng YJ, Li XH, Lin QX, Lin SG, Song YH, Li Y (corresponding author). The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor. Mol Cell Biochem, 332 (1-2): 25-32, 2009


23. Shan ZX, Lin QX, Deng CY, Zhu JN, Li Y, Lin SG, Yu XY. miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes. FEBS Lett, 584 (16): 2592-3600, 2010


24. Yu XY, Geng YJ, Liang JL, Lin QX, Lin SG, Zhang S, Li Y (corresponding author). High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor. Exp Cell Res., 316 (17):2903-2909, 2010


25. Li Y (corresponding author), Qu J, Shelat H, Gao S, Wassler M, Geng YJ. Clusterin induces CXCR4 expression and migration of cardiac progenitor cells. Exp Cell Res., 316 (20):3435-3442, 2010


26. Li Y (corresponding author), Geng YJ. A potential role for insulin-like growth factor signaling in induction of pluripotent stem cell formation. Growth Hormone & IGF Research. 20 (6): 391-398, 2010


27. Yu XY, Chen HM, Liang JL, Lin QX, Liu XY, Shan ZX, Yang M, Li Y (corresponding author), Lin SG. Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor. PLoS ONE, Jan25, 6(1):e16239, PMID:21283592, 2011


28. Hao CN, Geng YJ, Li F, Yang T, Su DF, Duan JL, Li Y (corresponding author).  Insulin-like growth factor-1 receptor activation prevents hydrogen peroxide - induced oxidative stress, mitochondrial dysfunction and apoptosis. Apoptosis, 16 (11):1118-1127, 2011


29. Li XH, Fu YH, Lin QX, Liu ZY, Shan ZX, Deng CY, Zhu JN, Yang M, Lin SG, Li Y, Yu XY. Induced bone marrow mesenchymal stem cells improve cardiac performance of infracted rat hearts. Mol Biol Rep. 39 (2): 1333-1342, 2012


30. Yu XY, Geng YJ, Liang JL, Zhang S, Lei HP, Zhong SL, Lin QX, Shan ZX. Lin SG, Li Y (corresponding author).  High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation. Mol Biol Rep. 39 (9): 8891-8898, 2012


31. Wang Y, Zhang Y, Zhang S, Peng G, Liu T, Li Y, Xiang D, Wassler MJ, Shelat HS, Geng Y. Rotating microgravity-bioreactor cultivation enhances the hepatic differentiation of mouse embryonic stem cells on biodegradable polymer scaffolds. Tissue Eng Part A. 18 (21-22): 2376-2385, 2012


32. Li Y (corresponding author), Shelat H, Geng YJ. IGF-1 prevents oxidative stress induced-apoptosis in induced pluripotent stem cells which is mediated by microRNA-1. Biochem Biophys Res Commun, 426 (4): 615-619, 2012


33. Li Y (corresponding author), Yang CM, Xi Y, Wu G, Shelat H, Gao S, Cheng J, Geng YJ. MicroRNA-1/133 targeted dysfunction of potassium channels KCNE1 and KCNQ1 in human cardiac progenitor cells with simulated hyperglycemia. International J of Cardiology, 167 (3): 1076-1078, 2013


34. Yu XY, Geng YJ, lei HP, Lin QX, Yuan J, Li Y (corresponding author).  IGF-1 prevents high glucose-induced cell cycle arrest in cardiomyocytes via β-catenin pathway. International J of Cardiology, 168 (3): 2869-2870, 2013


35. Li Y (corresponding author), Shen Z, Shelat H, Geng YJ. Reprogramming somatic cells to pluripotency: A fresh look at Yamanaka's model. Cell Cycle, 12 (23): 3594-3598, 2013


36. Zhang S, Zhang Y, Chen L, Liu T, Li Y, Wang Y, Geng YJ.Efficient large-scale generation of functional hepatocytes from mouse embryonic stem cells grown in a rotating bioreactor with exogenous growth factors and hormones. Stem Cell Res Ther. 4(6):145, 2013


37. Yang C, Madonna R, Li Y, Zhang Q, Shen WF, McNamara K, Yang YJ, Geng YJ. Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells.Vascul Pharmacol, 60 (1):8-16,2014


38. Huang W, Xiao DZ, Wang Y, Shan ZX, Liu XY, Lin QX, Yang M, Zhuang J, Li Y, Yu XY. Fn14 promotes differentiation of human mesenchymal stem cells into heart valvular interstitial cells by phenotypic characterization. J Cell Physiol, 229 (5):580-587,2014


39. Gao S, Wassler M, Zhang L, Li Y, Wang J, Zhang Y, Shelat H, Williams J, Geng YJ. MicroRNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis. Atherosclerosis. 232(1):171-179, 2014


40. Li Y (corresponding author), Shelat H, Wu H, Zhu M, Xu J, Geng YJ. Low circulating level of IGF-1 is a distinct indicator for the development of cardiovascular disease caused by combined hyperglycemia and dyslipidemia. International J of Cardiology, 171 (2): 272-273, 2014


41. Li Y (corresponding author), and Yu XY. Letter Regarding Article “Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity”. Circulation, 130 (8):e71.doi:10.1161, 2014


42. Li Y (corresponding author), and Shen Z. Letter Regarding Article “Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery”. Circulation, 130 (13):e117.doi.10.1161, 2014


43. Li Y (corresponding author), Shen Z, Yu XY. Transport of microRNAs via exosomes. Nat Rev Cardiol.  Apr;12(4):198. doi: 10.1038, 2015


44. Li Y (corresponding author), and Hong K. Letter Regarding Article “CrossTalk of Combined Gene and Cell Therapy in Ischemic Heart Disease: Role of Exosomal MicroRNA Transfer”. Circulation, 131(12):e384. doi: 10.1161, 2015


45. Li Y (corresponding author), and Hao CN. Letter Regarding Article “Transdifferentiation of Human Fibroblast to Endothelial Cells: Role of Innate Immunity”. Circulation, 132(15):e196 doi: 10.1161, 2015


46. Zhang Z, Yang J, Yan W, Li Y, Shen Z, Asahara, T. Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair. J Am Heart Assoc. 2016 Jan 25;5(1). pii: e002856. doi: 10.1161/JAHA.115.002856


47. Zhou J, Liu B, Liang C, Li Y (corresponding author), Song YH. Cytokine Signaling in Skeletal Muscle Wasting. Trends in Endocrinology & Metabolism. doi:10.1016/j.tem.2016.03.002


48. Li Y (corresponding author), Song YH, Yu XY. Letter Regarding Article, "MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis". Circulation, 133(24):e713doi: 10.1161, 2016


49. Li Y (corresponding author), Song YH, Liu B, Yu XY. The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research. International J of Cardiology, 227:191-193. 2017


50. Wang X, Zhi Q, Liu S, Xue SL, Shen C, Li Y, Wu C, Tang Z, Chen W, Song JL, Bao M, Song YH, Zhou J. Identification of specific biomarkers for gastric adenocarcinoma by ITRAQ proteomic approach. Sci Rep, 6:38871, 2016


51.Jiang XY, Feng YL, Ye LT, Li XH, Feng J, Zhang MZ, Shelat HS, Wassler M, Li Y, Geng YJ, Yu XY. Inhibition of Gata4 and Tbx5 by Nicotine-Mediated DNA Methylation in Myocardial Differentiation. Stem Cell Reports. 8(2):290-304, 2017


52.Shen C, Zhou J, Wang X, Yu XY, Liang C, Liu B, Pan X, Zhao Q, Song JL, Wang J, Bao M, Chaofan Wu C, Li Y (corresponding author), Song YH. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. Ebiomedicine (Lancet新子刊)16:238-250, 2017 


53. Shao L, Zhang Y, Lan B, Wang J, Zhang Z, Zhang L, Xiao P, Meng Q, Geng YJ, Yu XY, Li Y (corresponding author). MiRNA-sequence Indicates that Mesenchymal Stem Cells and Exosomes have Similar Mechanism to Enhance Cardiac Repair. Biomed Research International. 2017:4150705, 2017


54. Yangxin Li (corresponding author), Jin Zhou, Yao-Hua Song and Xi-Yong Yu. Dominant and recessive imprinting of exosomes from parent cells. Nature Reviews Cardiology. 14(8): 491, 2017


        55. Shen C, Song YH, Xie Y, Wang X, Wang Y, Wang C, Liu S, Xue SL, Li Y, Liu B, Tang Z, Chen W, Song J, Amin HM, Zhou J. Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway. Oncotarget., 8(44):76279-76289. doi: 10.18632/oncotarget.19348. 2017


        56. Yangxin Li (corresponding author), Bin Liu, Chun Liang. Letter by Li et al Regarding Article, “Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling”. Circulation, 136:2092-2093. doi: https://doi.org/10.1161/CIRCULATIONAHA.117.0297162017


57. 兰蓓蓓,王娟娟,邵联波,张 瑜,韩超珊,朱 宝,张鲁鲁,王燕丽,张雨晴,李杨欣. 间充质干细胞来源的外泌体通过TGF-β1/Smad2/3信号通路抑制高糖诱导的成纤维细胞转分化. 中国细胞生物学学报, 39(7):916-925, 2017


58. 张鲁鲁,朱 宝,张 瑜,王燕丽,张雨晴,谢文萍,严 兵,韩超珊,邵联波,李杨欣. 胰岛素样生长因子-1可以抑制氧化应激诱导的成纤维细胞的炎症反应. 中国血液流变学杂志. 28(1): 1-5,2018


59. Huang J, You H, Su C, Li Y, Chen S, Zheng C. Herpes simplex virus 1 tegument protein VP22 abrogates cGAS/STING-mediated antiviral innate immunity. Journal of Virology, JVI-00841, 2018


60. Bao M, Liu S, Yu XY, Wu C, Chen Q, Ding H, Shen C, Wang B, Wang S, Song YH, Li Y (corresponding author). Runx1 promotes satellite cell proliferation during ischemia-Induced muscle regeneration. Biochemical and biophysical research communications, 503(4), 2993-2997. 2018


61. Zhu B, Zhang L, Liang C, Liu B, Pan X, Wang Y, Zhang YQ, Zhang Y, Xie W, Yan B, Liu F, Yip H, Yu XY, Li Y (corresponding author) . Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through Novel Exosome/LncRNA MALAT1/NF-κB/TNF-α Signaling Pathway. Oxidative Medicine and Cellular Longevity , In Press 2018


62. Chaoshan Han, Jin Zhou, Bin Liu, Chun Liang, Xiangbin Pan, Yu Zhang,Yuqing Zhang, Yanli Wang, Lianbo Shao, Bao Zhu, Juanjuan Wang, Qian Yin, Xi-Yong Yu, Yangxin Li (corresponding author). Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging-induced vascular dysfunction in mouse hindlimb. Materials Science & Engineering C, In Press 2019


        科研项目:


2018-2022   国自然基金面上项目


2018-2021   国自然基金重大研究(培育)项目


2016-2019      江苏省双创团队领军


2016-2019     江苏省重点研发计划(社会发展)


2016-2019     苏州市民生科技项目


2012-2016      国家自然科学基金委员会重大国际合作项目


2014-2018      苏州大学启动基金


2015             优势学科奖励


 


团队成员:


  瑜,硕士,研究实习员


邵联波,博士研究生(已毕业,获国家奖学金、一等学业奖学金、校级优秀研究生称号)


韩超姗,博士研究生 (获学业奖学金特等奖)


 宝,博士研究生


王燕丽,博士研究生


兰蓓蓓,硕士研究生 (已毕业,获学业奖学金特等奖)


张鲁鲁,硕士研究生 (已毕业,获学业奖学金一等奖)


张雨晴,硕士研究生(获学业奖学金特等奖)


谢文萍,硕士研究生


  兵,硕士研究生


冯,硕士研究生


 


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